Molecular Formula | C36H48N4O10S |
Molar Mass | 728.8521 |
Solubility | 10 mM in DMSO |
Storage Condition | -20℃ |
Raw Materials | p-Toluenesulfonic acid |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.372 ml | 6.86 ml | 13.72 ml |
5 mM | 0.274 ml | 1.372 ml | 2.744 ml |
10 mM | 0.137 ml | 0.686 ml | 1.372 ml |
5 mM | 0.027 ml | 0.137 ml | 0.274 ml |
biological activity | Omadacycline tosylate are aminocycline antibiotics, which have antibacterial activity against gram-positive and negative aerobic bacteria and some anaerobic bacteria. |
Target |
bacteria |
in vitro study |
Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae) , with MIC 90 s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively.
|
in vivo study |
Omadacycline (0.11-18 mg/kg; a single I .v.) exhibits efficacy against Streptococcus pneumonia , Escherichia coli , and Staphylococcus aureus in mice systemic infection model, with ED 50 s ranging from 0.30 mg/kg to 3.39 mg/kg. |